CASE REPORT
Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 411-413

Chronic subdural hematoma-unsual cause of headache in a patient with chronic myeloid leukemia treated with high-dose imatinib mesylate: A rare case report with review of literature


Department of Radio-Diagnosis, Dr. D.Y. Patil Medical College, Pimpri, Pune, Maharashtra, India

Correspondence Address:
Sanjay M Khaladkar
Flat No. 5, Plot No. 8, S. No. 26/A, Tejas Bldg, Sahawas Society, Karve Nagar, Pune - 411 052, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-2870.157113

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Head injury is considered one of the single most important causes of subdural hematoma. Other cause include bleeding diasthesis. We report here a case of 70-year-old female patient with chronic myeloid leukemia (CML) presenting with bilateral chronic subdural hematoma after an incremental high-dose of imatinib mesylate (IM) due to loss of complete molecular response. IM is useful to treat a wide range of diseases, including Philadelphia chromosome-positive CML, as it has high tolerability and low incidence of minor side effects. Hemorrhage is a rare complication of IM. IM is associated with reduced α2-plasmin inhibitor and platelet dysfunction. This case report emphasizes on the need to consider chronic subdural hematoma as atypical cause of headache in a patient of CML taking high-dose IM.


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