CASE REPORT
Year : 2016  |  Volume : 9  |  Issue : 1  |  Page : 79-81

Carbimazole induced agranulocytosis with life-threatening complications, tremendous response with granulocyte-colony stimulating factor


1 Department of General Medicine, RKDF Medical College Hospital and RC, Bhopal, Madhya Pradesh, India
2 Department of Pathology, PCMS and RC, Bhopal, Madhya Pradesh, India
3 Department of Radiodiagnosis, RKDF Medical College Hospital and RC, Bhopal, Madhya Pradesh, India

Correspondence Address:
Seema Mahant
A312, Old Minal Residency, Bhopal, Madhya Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-2870.172437

Rights and Permissions

Agranulocytosis is a rare complication of drug carbimazole (0.23%). We are accounting to present a very interesting and rare case of agranulocytosis and neutropenic sepsis secondary to carbimazole that have tremendous response with recombinant human granulocyte colony-stimulating factor (G-CSF). A 35-year-old woman with hyperthyroidism since 1-month, who developed delayed carbimazole induced agranulocytosis. She presented with a fever, cough, sore throat and painful mouth ulcer since 7 day. Investigations revealed hyperthyroidism with neutropenia, white blood cell of 0.3 × 10 9 (neutrophils of 0.0 × 10 9 /L). Bone marrow aspiration revealed a hypocellular marrow with reduced myelopoiesis with minimal maturation, consistent with drug-induced neutropenia. G-CSF was used as an adjunctive therapy with discontinuation of carbimazole, barrier nursing and a broad-spectrum antibiotic (Third-generation cephalosporins) regimen to treat her neutropenic sepsis. Total white cell count and neutrophil count returned to normal on 5 days treatment and she made an uneventful recovery. She was subsequently rendered euthyroid with radioiodine treatment.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed15612    
    Printed109    
    Emailed0    
    PDF Downloaded349    
    Comments [Add]    
    Cited by others 1    

Recommend this journal