CASE REPORT |
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Year : 2016 | Volume
: 9
| Issue : 1 | Page : 79-81 |
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Carbimazole induced agranulocytosis with life-threatening complications, tremendous response with granulocyte-colony stimulating factor
Seema Mahant1, Upasana Shobhane2, PD Mahant3
1 Department of General Medicine, RKDF Medical College Hospital and RC, Bhopal, Madhya Pradesh, India 2 Department of Pathology, PCMS and RC, Bhopal, Madhya Pradesh, India 3 Department of Radiodiagnosis, RKDF Medical College Hospital and RC, Bhopal, Madhya Pradesh, India
Correspondence Address:
Seema Mahant A312, Old Minal Residency, Bhopal, Madhya Pradesh India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/0975-2870.172437
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Agranulocytosis is a rare complication of drug carbimazole (0.23%). We are accounting to present a very interesting and rare case of agranulocytosis and neutropenic sepsis secondary to carbimazole that have tremendous response with recombinant human granulocyte colony-stimulating factor (G-CSF). A 35-year-old woman with hyperthyroidism since 1-month, who developed delayed carbimazole induced agranulocytosis. She presented with a fever, cough, sore throat and painful mouth ulcer since 7 day. Investigations revealed hyperthyroidism with neutropenia, white blood cell of 0.3 × 10 9 (neutrophils of 0.0 × 10 9 /L). Bone marrow aspiration revealed a hypocellular marrow with reduced myelopoiesis with minimal maturation, consistent with drug-induced neutropenia. G-CSF was used as an adjunctive therapy with discontinuation of carbimazole, barrier nursing and a broad-spectrum antibiotic (Third-generation cephalosporins) regimen to treat her neutropenic sepsis. Total white cell count and neutrophil count returned to normal on 5 days treatment and she made an uneventful recovery. She was subsequently rendered euthyroid with radioiodine treatment.
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