|Year : 2017 | Volume
| Issue : 6 | Page : 522-525
QT-prolongation as an indicator of complications in malaria
Sudhindra Rao Mananje1, Shama Prakash Kabekkodu1, Ajitha Sharma2, Rama Prakasha Saya3
1 Department of General Medicine, K S Hegde Medical Academy, Mangalore, Karnataka, India
2 Department of Pharmacology, Kanachur Institute of Medical Sciences, Mangalore, Karnataka, India
3 Department General Medicine, Kanachur Institute of Medical Sciences and Research Center, Mangalore, Karnataka, India
|Date of Submission||06-May-2017|
|Date of Acceptance||30-Jul-2017|
|Date of Web Publication||17-Jan-2018|
Dr. Rama Prakasha Saya
Department General Medicine, Kanachur Institute of Medical Sciences and Research Center, Natekal, Mangalore - 575 018, Karnataka
Source of Support: None, Conflict of Interest: None
Introduction: There has always been a search for marker for predicting the complications of malaria. Electrocardiography (ECG) is a simple, easily available investigation, and QT-prolongation on ECG is a known marker of severity in many diseases. Aim: This study aimed to assess the association between QT interval prolongation and complications in malaria. Materials and Methods: This retrospective record-based study included 92 patients diagnosed with malaria by smear and was conducted from January to December 2013. The normal-corrected QT interval (QTC) was taken as 0.44 s (440 ms). Data were analyzed for association using Chi-square test and multivariate logistic regression model. Results: Mean QTC of the study group was 413.08 ± 34.8 ms. A total of 12 patients had QTC >440 ms, of them 10 had associated complications. Among 80 patients with normal QTC, 17 had complications associated with P < 0.001. Specificity of prolonged QTC for identifying complicated malaria was 83.33%, and sensitivity was 37.03%. On multivariate logistic regression model with QTC interval as the dependent variable, QTC was significantly associated with acute kidney injury (AKI) (P = 0.036) and Plasmodium vivax malaria (P = 0.01). Conclusions: Prolonged QTC has high specificity and low sensitivity for patients with complicated malaria. Prolonged QTC is significantly associated with vivax malaria and AKI in malaria. Hence, malaria patients with prolonged QTC should be more carefully watched for complications.
Keywords: Complications, electrocardiography, malaria, QT interval
|How to cite this article:|
Mananje SR, Kabekkodu SP, Sharma A, Saya RP. QT-prolongation as an indicator of complications in malaria. Med J DY Patil Univ 2017;10:522-5
|How to cite this URL:|
Mananje SR, Kabekkodu SP, Sharma A, Saya RP. QT-prolongation as an indicator of complications in malaria. Med J DY Patil Univ [serial online] 2017 [cited 2020 Feb 19];10:522-5. Available from: http://www.mjdrdypu.org/text.asp?2017/10/6/522/223377
| Introduction|| |
Malaria is endemic in many tropical countries accounting for large number of cases annually. Severe malaria is an enigmatic disease where many organs fail together or sequentially and can lead to the death of patients. The World Health Organization (WHO) has outlined the criteria for severe malaria depending on the available data, mostly from Africa, while severe anemia, cerebral malaria, acute kidney injury (AKI), multiple seizures, acute lung injury, circulatory collapse, etc., are included, cardiac complications or parameters are not included. There are few published studies and reviews about cardiac involvement in malaria.,,
There has always been a search for marker for predicting complications of malaria. Electrocardiography (ECG) is a simple, easily available investigation, and QT-prolongation on ECG is a known marker of severity in many diseases. The QT interval represents the length of ventricular electric systole, and its prolongation may provide the substrate for ventricular arrhythmias.
We tried to correlate the QT-prolongation with the complications of malaria in the present study. Like other febrile diseases, malaria increases the sympathetic tone in patients, leading to an acceleration of the electric conduction and repolarization of the heart, which can be shown as shortening of the QT intervals in electrocardiographic recordings. von Seidlein et al. found a correlation between parasitemia and corrected QT-prolongation in Gambian children with uncomplicated falciparum malaria. Another study on 161 patients with Plasmodium falciparum malaria, found abnormal ECG findings in 14.3% of all patients, including ST-segment or T-wave alterations in 15 patients and delayed conduction in eight patients.
| Materials and Methods|| |
This was a retrospective, record-based study conducted from January to December 2013. We collected data from Medical Records Department of a tertiary care hospital in coastal South India where malaria is endemic. Data of patients admitted with malaria diagnosed by peripheral blood smear examination and/or antibody-based rapid diagnostic testing were reviewed. A total 92 patients diagnosed with malaria were included in this study. The data were entered in a prestructured pro forma.
Complicated malaria was diagnosed based on the WHO guide lines. The definitions and the criteria for severe malaria included clinical jaundice or a serum bilirubin of >2.5 mg/dL, renal failure with a serum creatinine of >3 mg/dL, hypoglycemia with a whole blood glucose concentration <40 mg/dL, shock with a systolic blood pressure of <90 mmHg despite volume resuscitation, and severe anemia with a hemoglobin of <5 g/dL. Cerebral malaria is defined as unrousable coma not attributable to any other cause, with a Glasgow Coma Scale score ≤9. The diagnosis of malarial hepatitis was made with the demonstration of malarial parasite by peripheral smear examination or antibody-based rapid diagnostic testing and at least 3-fold rise in transaminase levels (alanine transaminase or aspartate transaminase) with or without conjugated hyperbilirubinemia; in the absence of clinical or serological evidence of viral hepatitis. Corrected QT (QTC) interval on ECG was calculated using Bazett's formula, QTC = QT/√RR interval. The normal QTC interval was taken as 0.44 s (440 ms).
Collected data were entered into Microsoft excel sheet and were analyzed for the association using Chi-square test and multivariate logistic regression model. The statistical analysis was done using Statistical Package for Social Sciences version 17 version (IBM Corp., Armonk, NY, USA). P < 0.05 was considered statistically significant.
| Results|| |
A total of 92 patients were selected, of them 78 were male and 14 were female [Table 1]. The important laboratory features were as per [Table 2]. Mean QTC of the study group was 413.08 ± 34.8 ms [Table 2]. With regard to complications, 14 patients had hepatitis, 5 patients had anemia, 4 patients had cerebral malaria, and 4 patients had AKI. On looking for patients having multiple complications, 5 patients had hepatitis and AKI, 1 patient had anemia and hepatitis, 1 patient had acute respiratory distress syndrome and hepatitis, and 1 patient had anemia with AKI and hepatitis [Table 3].
Twelve patients had QTC >440 ms, of them 10 had complications associated. Among 80 patients with normal QTC, 17 had complications associated with P < 0.001. Specificity of prolonged QTC for identifying complicated malaria was 83.33%, and sensitivity was 37.03% [Table 4]. Mean platelet count in study group was 88,380.43 cell/mm3. Mean platelet count in patients with prolonged QTC was 69,741.28 cell/mm3. This shows that patients with QT-prolongation had higher rate of complications and lower platelet count.
|Table 4: Association of corrected QT interval prolongation and complications of malaria|
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On multivariate logistic regression model with QTC interval as the dependent variable, QTC was significantly associated with AKI (P = 0.036) and Plasmodium vivax malaria (P = 0.01) [Table 5]. Mean serum potassium level in all patients was 3.8 mEq/L, and in patients with prolonged QTC was 3.68 mEq/L.
|Table 5: Multivariate logistic regression model with corrected QT interval interval as the dependent variable|
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| Discussion|| |
Studies looking into QT interval changes in malaria as a marker of complications are very few.,
The present study shows a QT-prolongation in 12 (13%) of patients admitted with malaria in tertiary care hospital of whom 10 (83.3%) had complications of malaria whereas among 80 (86.9%) patients without QT-prolongation, 17 (21.25%) had complications (P< 0.001). This shows a significant association of QTC prolongation with complicated malaria. QTC prolongation is shown to be highly specific for associated complications of malaria. However, its sensitivity is shown to be poor.
Roggelin et al. found a mean QTC was 422 ± 32 ms on admission, and the mean QTC was 413.08 ± 34.8 ms in the present study. Roggelin et al. also showed that QTC could get even more prolonged after initiating therapy. Since the present study is a retrospective study, no such information could be gathered.
On looking into the complications of malaria by multivariate logistic regression model with QTC interval as the dependent variable, the present study showed statistically significant association with renal failure only. Roggelin et al. showed statistically significant higher QT interval with patients with jaundice, acidosis, and respiratory distress.
The mean platelet count was lower in patients with prolonged QT interval in this study. Several studies indicated that low platelet count is associated with various malaria complications and thrombocytopenia may be used as a marker of severe malaria.,,
Soni et al. found prolonged QT interval in 26% of total malaria patients and QT-prolongation was significantly prolonged in patients with complicated malaria. This difference could have been due to the inclusion of more complicated malaria patients by Soni et al. than the present study. Franzen et al. showed ECG abnormalities in 22% of patients. Günther et al. found ECG abnormalities in 14% of patients.
Hypokalemia and hypocalcemia are two electrolyte disturbances which can lead to QTC prolongation. In the present study, mean serum potassium was marginally lower in patients with QTC prolongation. Serum calcium level was not considered in the present study. Another limitation is the retrospective nature of the study with a small sample size, and the QTC was not taken at follow-up or after the initiation of antimalarial drugs, which could alter the results.
| Conclusions|| |
Prolonged QTC was significantly associated with vivax malaria. Prolonged QTC has high specificity and low sensitivity for identifying patients with complicated malaria. Prolonged QTC is significantly associated with AKI in malaria. Hence, malaria patients with prolonged QTC should be more carefully watched for complications.
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Conflicts of interest
There are no conflicts of interest.
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[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]