TY - JOUR
A1 - Satav, Vikram
A1 - Sabale, Vilas
A1 - Kankalia, Sharad
A1 - Kadyan, Bhupender
A1 - Mulay, Abhirudra
A1 - Mane, Deepak
A1 - Singh, Rohit
A1 - Naveen, Thakur
T1 - Use of parenteral testosterone in hypospadias cases
Y1 - 2015/7/1
JF - Medical Journal of Dr. D.Y. Patil University
JO - Med J DY Patil Univ
SP - 495
EP - 498
VL - 8
IS - 4
UR - https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2015;volume=8;issue=4;spage=495;epage=498;aulast=Satav
DO - 10.4103/0975-2870.160804
N2 - Objectives: The aim was to evaluate the effect of parenteral testosterone on penile length, preputial hood, vascularity of dartos pedicle in patients with hypospadias. Materials and Methods: A total of 42 patients with hypospadias were included in this study. Injection aquaviron (oily solution each ml containing testosterone propionate 25 mg) was given deep intramuscularly in three doses with an interval of 3 weeks before reconstructive surgery at the dose of 2 mg/kg body weight. Preoperatively penile length, transverse preputial width and diameter at the base of the penis were measured. Basal testosterone levels were obtained before the institution of therapy and on the day of operation. Results: Following parenteral testosterone administration, the mean increase in penile length, transverse preputial width and diameter at the base of penis was 1.01 ± 0.25 cm (P < 0.001), 1.250 ± 0.52 cm and 0.61 ± 0.35 cm, respectively, (P < 0.001). Serum testosterone level after injection was well within normal range for that age. Conclusion: Parenteral testosterone increased phallus size, diameter and prepuce hypertrophy without any adverse effects. However, due to lack of a control group we cannot make any inferences. Controlled studies are required to establish the benefits of parenteral testosterone.
ER -