TY - JOUR A1 - Satav, Vikram A1 - Sabale, Vilas A1 - Kankalia, Sharad A1 - Kadyan, Bhupender A1 - Mulay, Abhirudra A1 - Mane, Deepak A1 - Singh, Rohit A1 - Naveen, Thakur T1 - Use of parenteral testosterone in hypospadias cases Y1 - 2015/7/1 JF - Medical Journal of Dr. D.Y. Patil University JO - Med J DY Patil Univ SP - 495 EP - 498 VL - 8 IS - 4 UR - https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2015;volume=8;issue=4;spage=495;epage=498;aulast=Satav DO - 10.4103/0975-2870.160804 N2 - Objectives: The aim was to evaluate the effect of parenteral testosterone on penile length, preputial hood, vascularity of dartos pedicle in patients with hypospadias. Materials and Methods: A total of 42 patients with hypospadias were included in this study. Injection aquaviron (oily solution each ml containing testosterone propionate 25 mg) was given deep intramuscularly in three doses with an interval of 3 weeks before reconstructive surgery at the dose of 2 mg/kg body weight. Preoperatively penile length, transverse preputial width and diameter at the base of the penis were measured. Basal testosterone levels were obtained before the institution of therapy and on the day of operation. Results: Following parenteral testosterone administration, the mean increase in penile length, transverse preputial width and diameter at the base of penis was 1.01 ± 0.25 cm (P < 0.001), 1.250 ± 0.52 cm and 0.61 ± 0.35 cm, respectively, (P < 0.001). Serum testosterone level after injection was well within normal range for that age. Conclusion: Parenteral testosterone increased phallus size, diameter and prepuce hypertrophy without any adverse effects. However, due to lack of a control group we cannot make any inferences. Controlled studies are required to establish the benefits of parenteral testosterone. ER -