ORIGINAL ARTICLE |
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Year : 2014 | Volume
: 7
| Issue : 1 | Page : 25-28 |
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Pancytopenia: A clinico-hematological study
Fahim Manzoor, Manjiri N Karandikar, Ravindra C Nimbargi
Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India
Correspondence Address:
Fahim Manzoor Alamgari Bazar near Makayas Provisional store, P.O. Nowshera-190011, Srinagar, J & K India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/0975-2870.122763
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Background: A review of both Western and Indian literature shows that there are few comprehensive studies on pancytopenia. In India, the causes of pancytopenia are not well defined. This data, if available, would help in planning the diagnostic and therapeutic approach in patients with pancytopenia. Aim: To evaluate the cases of pancytopenia by peripheral smear and/or bone marrow aspiration and/or bone marrow biopsy to find out the etiology, clinical, hematological, and histomorphologic features of pancytopenia. Materials and Methods: Detailed hematological investigations a complete hemogram, peripheral smear examination, bone marrow aspiration, and biopsy examination were done. Results: The most common cause of pancytopenia in our study was megaloblastic anemia (56%), followed by hypoplastic/aplastic anemia (14%), hypersplenism (8%) and post viral illness (6%). Conclusion: Megaloblastic anemia due to vitamin B12/folate deficiency seems to reflect the higher prevalence of pancytopenia in Indian subjects, putting hypoplastic/aplastic anemia in the second position, which is the leading cause for pancytopenia in the Western countries. |
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