ORIGINAL ARTICLE
Year : 2014  |  Volume : 7  |  Issue : 3  |  Page : 321-325

Kidney injury molecule-1: A urinary biomarker for contrast-induced acute kidney injury


1 Department of Biochemistry, Micropath Med.Center, Gurgaon, Haryana, India
2 Department of Biotechnology, Bharathiyar University, Coimbatore, Tamil Nadu, India
3 Department of Radiation Oncology, Salmaniya Medical Complex, Bahrain

Correspondence Address:
M Vijayasimha
Department of Biochemistry, Micropath Med.Center, Gurgaon, Haryana, India.

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-2870.128974

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Background: Urinary kidney injury molecule 1 (KIM-1) is an early biomarker for renal damage. A few studies have been published analyzing the potential use of urinary KIM-1 as a biomarker for acute kidney injury (AKI). However, no study has been done related to AKI associated with contrast administration. Aim: To search for new markers to identify AKI associated with contrast administration earlier than serum creatinine. Materials and Methods: We studied 100 consecutive patients with normal serum creatinine undergoing angiographic procedure. We assessed urine KIM-1, at 4, 8, and 24 hours after the angiographic procedure. Serum creatinine was measured at basal, 24, and 48 hours after the procedure. Results: There was a significant rise in urinary KIM-1 levels at 24 hours after the angiographic procedure. The presence of contrast induced nephropathy associated with AKI was 12%. Conclusion: The present study highlighted the importance of urinary KIM-1 in detecting AKI associated with contrast administration earlier than Serum creatinine.


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