Year : 2014  |  Volume : 7  |  Issue : 4  |  Page : 439-442

Comparison of antibiotic susceptibility pattern of community- and hospital-acquired methicillin-resistant Staphylococcus aureus with special reference to inducible clindamycin resistance in a tertiary care hospital in southern India

1 Department of Microbiology, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India
2 Department of Microbiology, KBNIMS, Gulbarga, Karnataka, India
3 Department of Pathology, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India
4 Department of Microbiology, SRMMC, Kanchipuram, Tamil Nadu, India

Correspondence Address:
Tandra Chadha
Department of Microbiology, Sree Narayana Institute of Medical Sciences, Chalakka, North Kuthiyatode - 683 594, Dist: Ernakulam, Kerala
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-2870.135257

Rights and Permissions

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community infections. Its prevalence varies markedly across different countries and among hospitals of the same country. Aims and Objectives: To estimate the prevalence of MRSA strains and investigate their antibiogram with special reference to inducible clindamycin resistance. Materials and Methods: All S. aureus isolates obtained from the clinical samples of microbiology laboratory were included in the study. All the isolates were identified by standard methods, and antimicrobial susceptibility testing was performed by Kirby Bauer disk diffusion method. Methicillin resistance was detected by combined cefoxitin and oxacillin disk diffusion method. Results were interpreted as per the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: A total of 362 S. aureus strains were isolated, of which 36.1% (131/362) isolates were MRSA. Of these, 79.4% (104/131) were hospital-acquired MRSA (HA-MRSA) and 20.6% (27/131) were community-acquired MRSA (CA-MRSA). All the isolates were sensitive to vancomycin. Inducible clindamycin [macrolide-lincosamide-streptogramin B (iMLS B )] resistance (D test) among MRSA isolates was 12.3% (16/131). HA-MRSA isolates showed 12.5% (13/104) D test positivity, as compared to 11.2% (3/27) seen in CA-MRSA isolates. Conclusion: The reported rate of MRSA incidence is alarming. Regular surveillance of hospital-acquired infections, isolation nursing of patients who carry MRSA, monitoring of antimicrobial susceptibility pattern, and formulation of a definite antibiotic policy may be helpful.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded421    
    Comments [Add]    
    Cited by others 3    

Recommend this journal