Year : 2015  |  Volume : 8  |  Issue : 1  |  Page : 103-105

Hyperhomocysteinemia presenting as Wallenberg syndrome: A report of two cases and review of literature

1 2nd year Resident, Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Medicine, University College of Medical Sciences, New Delhi, India
3 Department of Radiodiagnosis, University College of Medical Sciences, New Delhi, India

Correspondence Address:
Nikhil Gupta
Department of Medicine, University College of Medical Sciences, New Delhi - 110 095
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-2870.148869

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Wallenberg syndrome or lateral medullary syndrome occurs due to infarction of the lateral medulla usually supplied by the posterior inferior cerebellar artery (PICA). It most commonly results from occlusion of the vertebral artery followed by the PICA. The clinical manifestations result from impaired functioning of vestibular nuclei, inferior cerebellar peduncle, central tegmental tract, descending sympathetic fibers, nucleus ambiguus, spinothalamic tracts and spinal trigeminal nucleus. The clinical manifestations include dysphagia, nausea, vomiting, ataxia, Horner's syndrome, ipsilateral loss of pain and temperature over the face and contralateral loss over the trunk and body etc. Manifestations depend on the site of lesion. The most common etiology of Wallenberg syndrome being atherosclerotic occlusion of the arteries followed by secondary thrombosis. However, prothrombotic states rarely present as lateral medullary syndrome. Therefore, we report two cases of Wallenberg syndrome where patients were found to have hyperhomocysteinemia as a risk factor for the prothrombotic state.

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