Year : 2015  |  Volume : 8  |  Issue : 4  |  Page : 547-549

Childhood hepatitis A virus infection associated with immune thrombocytopenic purpura: Report of two cases

1 Department of Pediatrics, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
2 Department of Pediatrics, Golisano Children's Hospital, Upstate Medical University, Syracuse, New York, India
3 Department of Pediatrics, St. Mary's Hospital, PO30 5TG Newport, Wales, India

Correspondence Address:
Biswajit Biswas
Department of Pediatrics, Burdwan Medical College and Hospital, Burdwan - 713 104, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-2870.160827

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Hepatitis A virus (HAV) infection is a benign, self-limited gastrointestinal infection of the children belonging to the developing countries. Extra-intestinal, especially autoimmune hematological manifestations rarely develop during the course of infection in children. We describe two children, aged 8 months and 5 years who developed immune thrombocytopenic purpura (ITP) during the course of otherwise uncomplicated HAV infection. In both children, bleeding secondary to thrombocytopenia was the initial presentation. An 8-month-old infant was anicteric at presentation and HAV infection was discovered during the course of investigations. Both were treated with platelet concentrates and intravenous immunoglobulin therapy successfully. HAV should be included in the differentials in any child (including infants) who presents with ITP, even in the absence of well-recognized features of the disease.

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