TY - JOUR A1 - Khadem-Ansari, Mohammad-Hasan A1 - Ahani, Ali A1 - Mikaeili, Peyman A1 - Rasmi, Yousef T1 - Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat Y1 - 2014/7/1 JF - Medical Journal of Dr. D.Y. Patil University JO - Med J DY Patil Univ SP - 447 EP - 449 VL - 7 IS - 4 UR - https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=447;epage=449;aulast=Khadem-Ansari DO - 10.4103/0975-2870.135259 N2 - Background: Benzodiazepines are widely used as psychoactive agents and the side effects of benzodiazepines to the endocrine system are reported. Objective: This study was designed to explore the effects of the benzodiazepines - lorazepam and clonazepam - on thyroglobulin (Tg), anti-thyroglobulin (aTg), anti-thyroid peroxidase (aTPO), and thyroid stimulating hormone (TSH). Materials and Methods: Eighteen male Wistar rats were randomly divided into three groups: control (C), lorazepam-treated, and clonazepam-treated groups. The changes in Tg, aTg, aTPO, and TSH in these three groups were compared after 4 weeks. Results: The levels of Tg and aTg in the lorazepam-treated and clonazepam-treated rats significantly increased compared to the control group. But there was no significant difference in the levels of TSH and aTPO between lorazepam-treated and clonazepam-treated rats in comparison with the control group rats. Conclusion: The thyroid gland is affected by lorazepam and clonazepam, which are used in epilepsy, bruxism, anxiety, insomnia, and other psychic disorders. ER -