RT - Journal TY - JOUR A1 - Banerjee, Sourindra A1 - Ta, Rupam A1 - Roy, Arnab A1 - Barman, Pratik T1 - Systemic sclerosis complicated with malignant pleural effusion with high serum CA-125 tumor marker YR - 2015/12/1 JF - Medical Journal of Dr. D.Y. Patil University JO - Med J DY Patil Univ SP - 826 OP - 829 VO - 8 IS - 6 UL - https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2015;volume=8;issue=6;spage=826;epage=829;aulast=Banerjee;t=5 DO - 10.4103/0975-2870.169934 N2 - The malignant pleural effusion in systemic sclerosis (SSc) is an uncommon condition than its common manifestation like interstitial lung fibrosis, pulmonary hypertension, and lung malignancy. We reported here a case of malignant pleural effusion in a 40-year-old female suffering from SSc with high serum tumor marker "cancer antigen-125 (CA-125)". Computed tomogram guided fine needle aspiration cytology from the lung nodule revealed adenocarcinoma lung. The frequency or reasons of an elevated level of a serum or pleural fluid CA-125 in this case are unclear. Excepting ovarian and lung malignancy, increased CA-125 level in serum, and pleural fluid is also detectable in nonmalignant conditions including SSc as a part of serositis. We emphasized here the malignant potential of SSc and the need for long-term follow-up to detect underlying malignancy. High CA-125 level might be interpreted cautiously. ER -