ORIGINAL ARTICLE
Year : 2014 | Volume
: 7 | Issue : 4 | Page : 447--449
Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat
Mohammad-Hasan Khadem-Ansari1, Ali Ahani2, Peyman Mikaeili3, Yousef Rasmi1 1 Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran 2 Department of Veterinary, Islamic Azad University-Urmia Branch, Urmia, Iran 3 Department of Pharmacology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Correspondence Address:
Yousef Rasmi Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia Iran
Background: Benzodiazepines are widely used as psychoactive agents and the side effects of benzodiazepines to the endocrine system are reported. Objective: This study was designed to explore the effects of the benzodiazepines - lorazepam and clonazepam - on thyroglobulin (Tg), anti-thyroglobulin (aTg), anti-thyroid peroxidase (aTPO), and thyroid stimulating hormone (TSH). Materials and Methods: Eighteen male Wistar rats were randomly divided into three groups: control (C), lorazepam-treated, and clonazepam-treated groups. The changes in Tg, aTg, aTPO, and TSH in these three groups were compared after 4 weeks. Results: The levels of Tg and aTg in the lorazepam-treated and clonazepam-treated rats significantly increased compared to the control group. But there was no significant difference in the levels of TSH and aTPO between lorazepam-treated and clonazepam-treated rats in comparison with the control group rats. Conclusion: The thyroid gland is affected by lorazepam and clonazepam, which are used in epilepsy, bruxism, anxiety, insomnia, and other psychic disorders.
How to cite this article:
Khadem-Ansari MH, Ahani A, Mikaeili P, Rasmi Y. Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat.Med J DY Patil Univ 2014;7:447-449
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How to cite this URL:
Khadem-Ansari MH, Ahani A, Mikaeili P, Rasmi Y. Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat. Med J DY Patil Univ [serial online] 2014 [cited 2024 Mar 29 ];7:447-449
Available from: https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=447;epage=449;aulast=Khadem-Ansari;type=0 |
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