Medical Journal of Dr. D.Y. Patil Vidyapeeth

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 7  |  Issue : 4  |  Page : 447--449

Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat


Mohammad-Hasan Khadem-Ansari1, Ali Ahani2, Peyman Mikaeili3, Yousef Rasmi1 
1 Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Veterinary, Islamic Azad University-Urmia Branch, Urmia, Iran
3 Department of Pharmacology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Correspondence Address:
Yousef Rasmi
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia
Iran

Background: Benzodiazepines are widely used as psychoactive agents and the side effects of benzodiazepines to the endocrine system are reported. Objective: This study was designed to explore the effects of the benzodiazepines - lorazepam and clonazepam - on thyroglobulin (Tg), anti-thyroglobulin (aTg), anti-thyroid peroxidase (aTPO), and thyroid stimulating hormone (TSH). Materials and Methods: Eighteen male Wistar rats were randomly divided into three groups: control (C), lorazepam-treated, and clonazepam-treated groups. The changes in Tg, aTg, aTPO, and TSH in these three groups were compared after 4 weeks. Results: The levels of Tg and aTg in the lorazepam-treated and clonazepam-treated rats significantly increased compared to the control group. But there was no significant difference in the levels of TSH and aTPO between lorazepam-treated and clonazepam-treated rats in comparison with the control group rats. Conclusion: The thyroid gland is affected by lorazepam and clonazepam, which are used in epilepsy, bruxism, anxiety, insomnia, and other psychic disorders.


How to cite this article:
Khadem-Ansari MH, Ahani A, Mikaeili P, Rasmi Y. Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat.Med J DY Patil Univ 2014;7:447-449


How to cite this URL:
Khadem-Ansari MH, Ahani A, Mikaeili P, Rasmi Y. Effect of benzodiazepines on thyroglobulin, anti-thyroglobulin, anti-thyroid peroxidase, and thyroid stimulating hormone in rat. Med J DY Patil Univ [serial online] 2014 [cited 2024 Mar 29 ];7:447-449
Available from: https://journals.lww.com/mjdy/pages/default.aspx/article.asp?issn=0975-2870;year=2014;volume=7;issue=4;spage=447;epage=449;aulast=Khadem-Ansari;type=0