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Figure 3: Showing the relation between the HbS polymerization and intracellular acidic pH as the main reason for the RBC dehydration in sickle cell disease as per our proposed theory. Along with the Jacobs and Steward mechanism (J-S), elevated intracellular lactic acid also plays a key role in the depletion of K+ ion from the RBC and further causes rapid anaerobic glycolysis due to acidic pH (which again polymerize sickled RBC) in sickle cell disease (Virgilio and Robert, 2005)[14] |
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